Effect of dichlorvos on tissue esterases in rats

Abstract

The effect of dichlorvos was investigated on various tissue csterases in rats after single oral admintstration (60 mg/kg). It produced significant (P < 0.05) inhibition of cholinesterase and carboxylestcrase enzymes in all tissues within 30 mm after administration. At 3 h, maximum inhibition in cholinesterase and carboxylesterase enzyme levels wsa recorded in blood (45%) and lever (58%) respectively. The present investigation reveals dichlorvos to be a potent inhibitor of tissue esterases, in vivo, and its exposure may impair biotransformation of xenobiotics that are mainly biodegraded by carboxylesterase enzyme.