Progress of an anti-convulsant drug from discovery to manufacture

Mukund S Chorghade, Elaine C Lee

Abstract


Inhibition of GABA uptake is a useful strategy in the design of anti-convulsants. The development of an anti- epileptic drug from disovery to process development and manufacture is described. Synthesis of the human metabolite and tablet degradates has been achieved.

Keywords


GABA uptake; anti-convulsants; anti-epileptic; synthesis; metabolite; degradates.

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