ACTIVATION OF MURINE THYMOCYTES in vivo. PART 1. STUDY OF BLASTOGENESIS AND DNA SYNTHESIS AFTER STIMULATION WITH CONCANAVALIN A.

Abstract

The present study establishes that a polyclonal stimulater like Concanavalin A can stimulate the marine lymphocytes in vivo in different lymphoid organs and peripheral blood. The process of stimulation has been investigated by studying blastogenesis and DNA synthesis of lymphocytes after injecting this substance in mice. Different doses of this substance cause differential response of blastornesis and DNA synthesis by the lymphocytes. The implications of the findings and the necessity of the study have been discussed.