Spatio‑Temporal Control of Cellular and Organismal Physiology by Sirtuins

Abstract

The survival of an organism is intricately dependent upon its
ability to sense and respond to both extracellular and intracellular cues.
In the context of metabolic or nutrient sensing while intracellular signaling
ensures synchronization of various metabolic pathways, inter-tissue
communication enables the organism to couple energetic needs of all
the organ systems and in a concerted manner. In this review, we highlight
the role of evolutionarily conserved sirtuins (NAD-dependent deacylases)
in synchronizing inter-organellar and inter-tissue cross-talk that is
needed to orchestrate organism-wide metabolic homeostasis.