Chemistry and biochemical pharmacology of cardiac glycosides - A review

R VENKATESWARA RAO, C S VAIDYANATHAN

Abstract


Cardiac glycosides constitute one of the most important categories of pharmacological agents of plant origin used in the clinical management of cardiac failure. The present review deals with the current ideas on the structure-activity relationships (SAR) and the biochemical mechanism of cardiac glycoside-induced positive inotropy. Divergent modern concepts on the role of calcium in the cardiac glycoside-induced cardiotonic effects are discussed.

Keywords


Cardiac glycosides; cardenolides; Na; K-ATPase; positive inotropy; structure-activity relationships (SAR).

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