Polyclonally stimulated murine T cells in control of fibrosarcoma in situ

Abstract

Adoptive transfer of in vivo Concanavalin A (Con A)-activated syngeneic lymphocytes at the tumour site of mice could more effectively cut through; MCA-induced tumour growth than injecting Con A, a polyonal activator for T lymphocytes, in the tumour- bearing hosts. If these effector lymphocytes were depleted of suppressor T cells by treatment with low dose of cyclophosphalnlde (CY), the inhibition of the tumour growth was better. The cytotoxic ability of these effector cells against Cr_labelled tumour-target cells seemed to be doubly effective than the Con A-stimulated cell population as such.