Debenzylation by Ni-AI alloy
Abstract
Nickel-aluminum alloy in aqueous sodium hydroxide-ethanol medium brings about facile hydrogenolysis of benzyl ether function in substrates carrying a vicinal methoxy group. Simplicity of the reaction conditions and cheapness of the reagent are some of the advantages of the procedure. Additionally, carbonyl functions when present are untouched and alkaline medium of the reaction makes it compatible with the presence of acid-sensitive groups.
Keywords
Ni-Al alloy; benzyl ether cleavage; hydrogenolysis; debenzylalion.
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