Studies on chelation reaction of cyclophosphamide (CPM), a valuable anti-cancer drug with carcinogenic metal ions Cu(II) and Co(II)

G C BHATNAGAR, S B SAXENA

Abstract


The chelation  reaction  cyclophosphamide (CPM),an  anti-cancer biological  alkylating agent  of  nitrogen mustard  group  with  Cu(l1)  and  Co(ll),  has  been  investigated potentiometrically. The stability constrants have been  reported  at temperatures 21°C  and  41°C  +/1 1°C  and  u=0.05M 0.10M  and 0.2OM (KNO3)  1.1  stoichiometry of  metal  liand  interaction  has been confirmed by conductometry.  Negative values of  G and  positive values of  S  indicate  stable  complex  formation.

Keywords


Cyclophosphamide; anti-cancer drug; carcinogenic metal ions Cu(ll) and Co(ll); stability constant.

Full Text:

PDF

Refbacks

  • There are currently no refbacks.