PREPARATION OF 3: 4-DICHLORO- AND 3: 4: 5-TRICHLORO-ANILINES

Abstract

During  a  course  of  research  on  synthetic  antimalarials,  it  was  required  to  prepare  large  quantities  of  3:  4-dichloro- and  3:  4:  5-trichloro-anilincs.  A  survey  of  the  literature  showed  that  the  syntheses  of  3:  4-dichloro- and  3:  4:  5-trichloro-anilines  have  been  accomplished  by  many  chemists,  but  nowhere  any  details  were  recorded.  It  was,  therefore,  thought  desirable  to  investigate  into  their  methods  of  preparation  with  a  view  to  finding  out  the  best  one  and  ascertaining  necessary  details  for  the  successful  laboratory  and  semi-large-scale  preparation  of  these  valuable  amines.