Surface mediated reaction-A powerful technique in organic synthesis. Use of alumina and silica gel as active surface for useful synthetic transformations

Brindaban C Ranu, Sanjay Bhar, Rupak Chakraborty, Asish Ranjan Das, Manika Saha, Arunkanti Sarkar, Ratna Chakraborti, Dipak C Sarkar

Abstract


Significant improvement in terms of convenience, yield, reaction time and selectivity has been achieved using alumina and silica gel as support or surface for several Important reactions. These include : (a) Michael reaction, (b) regioselective alkylation of 1.3-dicarbonyl compounds. (c) selective bromination of alkyl- substituted aromatic hydrocarbons, (d) aldol reaction of silyl enol ethers with aldehydes, (e) regioselectwe reductwe cleavage of epoxides, (fl regioselective hydration of alkenes, and (g) regioselective 1.2-reduction of conjugated carbonyl compounds.

Keywords


Surface-mediated reaction; silica gel; alumina; Michael reaction; alkylation; aldol reaction; epoxidecleavage; hydration of alkenes; reduction of conjugated carbonyl compounds.

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