N-[2-NAPHTHYL] GLYCINE HYDRAZIDE - A POTENT INHIBITOR OF Myrobacterium tuberculosis H37Rv

Abstract

N[2-naphthyll glycine hydrazide (compound MC 1415) was found to completely inhibit the growth of Mycobacterium tuberculosis H37 Rv at 1 ug/ml when tested in Youman's medium. The dihydrochloride salt of the compound was prepared and found to have the same level of biological activity as the parent compound in equimolar amount. In the presence of human serum in the medium the activity of both against M. tuberculosis is reduced ten-fold (there is partial inhibition of growth of the organism at 10fig/ml). The LD 50 of the dihydrochloride in mice by the intraptritoneal and oral routes was found to be 246.6 mg/kg and 593 mg/kg respectively.