THE PHARMACOLOGY OF SOME CYCLOHEXANOL DERIVATIVES.

Abstract

Besides ethanol, the tertiary amyl alcohol (2-methyl-2-butanol) is the  only simple alcohol which has found practical use as an hypnotic.  The  recent studies on the simple highly unsaturated carbinols as hypnotics has  activated the interest for a systematic study of these groups of compounds  as therapeutic agents.

Evaluation of the hypnotic and anesthetic activities of a group of  cyclohexanol derivatives, and a study of the toxicity and pharmacodynamic  action of few of the active ones has revealed that some of these compounds  produce rapid hypnosis and anesthesia of short duration.

Of the substances tested, 2-methyl-1-ethinyl cyclohexanol was the  least toxic with a chemo-therapeutic ratio of more than 5.

These preliminary studies indicate the possibility of obtaining rapid  hypnotic and short acting anesthetics in these cyclohexanol derivatives.