Recent NMR Methodological Developments for Chiral Analysis in Isotropic Solutions

Sachin Rama Chaudhari, Suryaprakash N

Abstract


Chiral auxiliaries are used for NMR spectroscopic study of enantiomers. Often the presence of impurities, severe overlap of peaks, excessive line broadening and complex multiplicity pattern restricts thechiral analysis using 1D 1H NMR spectrum. There are few approaches to resolve the overlapped peaks. One approach is to use suitable chiralauxiliary, which induces large chemical shift difference between the discriminated peaks (ΔδR,S) and minimize the overlap. Another directionof approach is to design appropriate NMR experiments to circumvent some of these problems, viz. enhancing spectral resolution, unravelling the superimposed spectra of enantiomers, and reduction of spectral complexity.Large number of NMR techniques, such as two dimensional selectiveF1 decoupling, RES-TOCSY, multiple quantum detection, frequency selective homodecoupling, band selective homodecoupling, broadband homodecoupling, etc. have been reported for such a purpose. Many ofthese techniques have aided in chiral analysis for molecules of diverse functionality in the presence of chiral auxiliaries. The present review summarizesthe recently reported NMR experimental methodologies, with aspecial emphasis on the work carried out in authors’ laboratory.

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