Methods and Developments in Graphical Pangenomics

Abstract

Pangenomes are organized collections of the genomic information
from related individuals or groups. Graphical pangenomics is the
study of these pangenomes using graphical methods to identify and analyze
genes, regions, and mutations of interest to an array of biological
questions. This field has seen significant progress in recent years including
the development of graph based models that better resolve biological
phenomena, and an explosion of new tools for mapping reads, creating
graphical genomes, and performing pangenome analysis. In this review,
we discuss recent developments in models, algorithms associated with
graphical genomes, and comparisons between similar tools. In addition
we briefly discuss what these developments may mean for the future of
genomics.