Foetotoxic effect of potassium chromate (K2CrO4) in Swiss albino mice

B GOWRISHANKAR, O S VIVEKANANDAN, B R SRINATH, K R SHIVA KUMAR, K R RAMA RAO

Abstract


The embryotoxic and teratogenic potential of potassium chromate was evaluated by the teratological analysis of mouse foetuses. The test chemical was administered intraperitoncally to laboratory-bred Swiss albino mice of both sexes for 30 days. Teratological scanning of the foetuses born to treated animals revealed a reduction in the number of live implants and litter size. Higher incidence of resorption and dead litter indicated the embryotoxic effect of the test chemical Malfonnations, both skeletal and morphological, suggest the possibility of potassium chromate( K2Cr04) being foetotoxic.

Keywords


Carcinogen; embryocidal; ossified foetuses; prenatal death.

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