Synthesis of optically active steroids-achievements and aspirations

A SARKAR, V PURUSHOTHAM, T R KASTURI

Abstract


Different approaches to obtain steroids in high optical purity have been discussed. Utility of syntheses from natural precursors, resolution of intermediates and selective derivatizations using chiral reagents have been highlighted. The mechanisms of different asymmetric syntheses have been reviewed. A mechanism involving bifunctional catalYsis has been proposed for amino acid catalyzed asymmetric cydization reactions on the basis of available literature data.

Keywords


Optically active steroids; optical resolution; thermodynamically controlled asymmetric derivatizations; asymmetric synthesis; diastereomeric transition states; intramolcuular asymmetrlc induction; chiral recognition; bifunctional catalysis.

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