Studies on some HMP pathway enzymes in gal mutants of Aspergillus nidulans

Abstract

Biochemical studies carried out with galactose non-utliising mutants of microorganisms demonstrated that the enzymlic defect in these mutants is similar to the enzymic defect seen in galactosemks. In the present study, we carried out investigations on three enzymes of trbe HMP pathway in some gal mutants of Aspergillus nidulans. The study indicates that this pathway is disturbed in these mutants When they are cultured in the presence of galactose, which may suggest that galactose and some of its metabolites which are said to accumulate in the galactosemic condition may impair the lIMP pathway in this state.